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Procalcitonin is an acute- phase reactant that may be helpful in differentiating between infectious or non- infectious causes in patients with systemic inflammatory response syndrome. Procalcitonin serum levels increase during severe generalized bacterial, parasitic or fungal infections with systemic manifestation. In severe viral infections, or inflammatory reactions of non- infectious origin, procalcitonin levels do not increase, or only show a moderate rise. Procalcitonin levels increase with the severity of the inflammatory response to infection. Existe una alta morbilidad y mortalidad por esta causa, siendo. 13 Ponencia mixta: sepsis de transmisi La procalcitonina (PCT) ha sido descrita como un marcador especifico de infecciones bacterianas. Objetivos: Comparar el valor predictor de la PCT, Prote Todo el contenido de esta revista, excepto d Therefore, procalcitonin may serve as an important indicator of the severity and prognosis of infection. It also and allow judgment of the efficacy of therapeutic measures. Key words: Procalcitonin, inflammatory response syndrome, marker Introducci. Sin embargo, de las pruebas diagn. El marcador ideal de infecci. Al establecerse los m. Comparada con otros par. A diferencia de otros reactantes de fase aguda y marcadores de inflamaci. Por lo tanto, puede ser utilizada para el diagn. A su vez, la PCT es precursor de tres mol. Al igual que otras prote. No se ha establecido una v. Los niveles de PCT se incrementan a las 3- 4 horas, alcanzan un pico cerca de las 6 horas y una meseta despu. Es probable que las infecciones bacterianas, al ser un fen. Los valores normales en sangre son menores de 0. L. Valores mayores de 0. L son considerados anormales. Entre 0. 5 ng/m. L y 2 ng/m. L representan una elevaci. Determinaciones mayores de 1. L son casi exclusivamente indicativas de sepsis grave, choque s. Los niveles de PCT se incrementan ligeramente en respuesta a infecciones virales, infecci. Niveles muy levados de PCT indican infecci. Indicaciones primarias para la determinaci. Manejo y seguimiento de enfermedades inflamatorias de origen desconocido: Determinar la etiolog. La PCT ha sido propuesta recientemente como un marcador de infecci. Los valores de PCT en el rango de 5- 1. L han sido propuestos por diversos autores como un valor l. Procalcitonina en pacientes con infecciones de v. Los pacientes con sospecha de infecci. Desarrollaron un estudio aleatorizado, ciego, comparando un grupo con tratamiento est. Encontraron un riesgo relativo corregido de 0. PCT en cuanto a la exposici. Brunkhorst y colaboradores 2. Veintisiete pacientes con SIRA de causa conocida (1. SIRA de origen no s. Repse y colaboradores 4. PCT como marcador de gravedad en pancreatitis aguda (PA). Incluyeron 5. 6 pacientes con PA y de acuerdo al curso cl. Los valores de PCT fueron comparados con otros indicadores de gravedad. Los pacientes en los grupos II y III tuvieron niveles m. Sin embargo, en un estudio posterior estos hallazgos no fueron reproducidos cuando las determinaciones de PCT fueron realizadas en las primeras 2. Mandi y colaboradores. PCT de pacientes con necrosis pancre. Encontraron diferencia significativa entre ambos grupos, los resultados precedieron la positividad de los cultivos bacterianos en estos pacientes, con sensibilidad del 9. Procalcitonina en pacientes con cirug. Otra de las aplicaciones cl. En pacientes con cirug. Lechamy y colaboradores. Procalcitonina en pacientes con enfermedades inmunol. Las infecciones bacterianas graves son una complicaci. Representa un reto realizar el diagn. En pacientes con LES y vasculitis asociada a anticuerpos anticitoplasma de neutr. Eberhard y colaboradores. Shin y colaboradores,2. LES y fiebre, demostraron que los pacientes con infecciones bacterianas presentaron niveles de PCT promedio de 0. L, siendo significativamente mayores a los niveles de PCT de pacientes con infecciones virales o actividad de la enfermedad autoinmune (p < 0. La tabla 2 enumera las indicaciones primarias donde la cuantificaci. Indicaciones primarias para la determinaci. Conclusiones En los pacientes cr. Los pacientes ancianos y los inmunocomprometidos pueden presentar infecciones graves sin SRIS. El tratamiento temprano de pacientes infectados mejora el pron. A pesar de la amplia disposici. Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1. 99. 3; 3. Le Moullec JM, Julliene A, Chenais J, et al. The complete sequence of human preprocalcitonin. Becker KL, O'Neill WJ, Snider RH. Hypercalcitonemia in inhalation burn injury: a response of the pulmonary neuroendocrine cell? Anat Rec 1. 99. 3; 2. Wrenger S, Kahne T, Bohuon C, et al. Amino- terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV. Meisner M, Schmidt J, Huettner H, et al. The natural elimination rate of procalcitonin in patients with normal and impaired renal function. Int Care Med 2. 00. The plasma elimination rate and urinary secretion of PCT in patients with normal and impaired renal function. Anesthes 1. 99. 9; 9. Suppl. 3. A: A2. 36. Dandona P, Nix D, Wilson MF. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1. Brunkhorst FM, Heinz U, Forycki ZF. Kinetics of procalcitonin in iatrogenic sepsis. Int Care Med 1. 99. Calcitonin gene expression in normal human liver. Nijsten MW, Olinga P, The TH. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med 2. 00. Procalcitonin in acute malaria. Eur J Res 1. 99. 7; 2: 2. Gerard Y, Hober D, Petitjean S, et al. High serum procalcitonin level in a 4- year old liver transplant recipient with disseminated candidiasis. Infection 1. 99. 5; 2. Zeni F, Viallon A, Assicot M, et al. Procalcitonin serum concentrations and severity of sepsis. Clin Int Care 1. 99. Ugarte H, Silva E, Mercan D, et al. Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med 1. 99. Muller B, Becker KL, Schachinger H, et al. Calcitonin precursors are reliable marker of sepsis in a medical intensive care unit. Crit Care Med 2. 00. Bell K, Wattie M, Byth K, et al. Procalcitonin: a marker of bacteraemia in SIRS. Anaesth Int Care 2. The value of procalcitonin as an infection marker in cardiac surgery. Eur J Med Res 2. 00. Serum procalcitonin levels in bacterial and viral meningitis. Neurology 1. 99. 9; Suppl. A: 4. 21- 2. Riche F, Bernard P, Laisn. Inflammatory cytokines, C reactive protein, and procalcitonin as early predictors of necrosis infection in acute necrotizing pancreatitis. Surgery 2. 00. 3; 1. Mandi Y, Farkas G, Takacs T, et al. Diagnostic relevance of procalcitonin, IL- 6, and s. ICAM- 1 in the prediction of infected necrosis in acute pancreatitis. Inter J Pancreatol 2. Early identification of biliary pancreatitis with procalcitonin. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Ann Rheum Dis 2. 00. Gendrel D, Raymond J, Assicot M, et al. Measurement of procalcitonin levels in children with bacterial and viral meningitis. Clin Infect Dis 1. Brunkhorst FM, Eberhard OK, Brunkhorst R. Discrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitonin. Crit Care Med 1. 99. Giamarellou H, Athanassiou K, Bouza E, et al. Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study. Clin Microbiol Infect. Kuse E, Langefeld I, Jaeger K. Procalcitonin in fever of unknown origin after liver transplantation: A variable to differentiate acute rejection from infection. Crit Care Med 2. 00. Shin KC, Lee Y J, Kang SW, et al. Serum procalcitonin measurement for detection of intercurrent infection in febrile patients with SLE. Annals of Rheumatic Diseases 2. Moosig F, Csernok E, Reinhold- Keller E. Elevated procalcitonin levels in active Wegener. J Rheumatol 1. 99. Eberhard O, Haubitz M, Brunkhorst FM. Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematosus/systemic antineutrophil cytoplasmic antibodies- associated vasculitis) and invasive bacterial infection. Arthritis and Rheum 1. Fritz H, Brandes GH, Bredle DL, et al. Post- operative hypoalbuminaemia and procalcitonin elevation for prediction of outcome in cardiopulmonary bypass surgery. Acta Anaesthesiol Scand 2. Oczenski W, Fitzgerald R, Schwarz S. Procalcitonin: a new parameter for the diagnosis of bacterial infection in the peri- operative period. Eur J Anaesthesiol 1. Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Hergert M, Lestin HG, Scherkus M, et al. Procalcitonin in patients with sepsis and polytrauma. Clin Lab 1. 99. 8; 4. Chan Y, Tseng CP, Tsay P, et al, Procalcitonin as a marker of bacterial infection in the emergency department: an observational study. Crit Care 2. 00. 4; 8: R1. Clec CH, Ferriere F, Karoubi P, et al. Diagnostic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med 2. 00. Lee Y, Park CH, Yun J, et al. Predictive comparisons of procalcitonin (PCT) level, arterial ketone body ratio (AKBR), APACHE III score multiple organ dysfunction score (MODS) in systemic inflammatory response syndrome (SIRS). Oberhoffer M, Stonans l, Russwurm S, et al. Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis related cytokines in vitro. J Lab Clin Med 1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1. 99. Definitions for sepsis and organ failure. Crit Care Med 1. 99. Differential diagnostik der abstossungsreaktion und infektion bei herztransplantierten patienten: neue wege mit zytokinen und procalcitonin als marker. Transplantation medizin 1. Kollef MH, Sherman G, Ward S, et al. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Download el viaje de teo epub descargar files for free. Tracklist : 0. 1. Sabor A Traicion - 0. Entre Tu Y Yo - 0. Encadenarme A Tu Piel - 0. Al Filo De La Razon - 0. ![]() En Brazos De La Eternidad - 0. 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Below the central COMAND screen are silver effect air vents, and a square, analog clock within the vents. Below the vents are metal tab switches with a black field behind them, to control the HVAC system (these functions are all also accessible via the COMAND system, which also offers access to some additional HVAC functions, such as foot- well temperature settings and air flow control). Below the HVAC button section is a panel that opens to give access to the DVD changer which also includes a Compact. Flash card reader. On the center console, a metal control wheel for the COMAND system sits above a piece of wood, surrounded by metal buttons. There is no longer a central gear shift lever as in previous models, instead a stalk on the steering wheel controls the gearbox (with buttons or, optionally, paddles on the steering wheel for manual gear control). Controls mounted on the door panels provide access to the main seat controls (including the optional seat heating, seat ventilation and memories) and to the electrical mirrors, windows and boot lid opening and closing. Additional seat controls are accessed via the standard COMAND system (these include controlling the optional multi- contour and dynamic driving seats and the massaging seat functions). Throughout the interior, many buttons are metal, with black fields above them denoting the switches' function. The steering wheel has various control buttons for the cluster display, volume and telephone control and for the optional Linguatronicvoice control system. On the electrically adjustable steering wheel column are also mounted the gearbox control lever, the stalk for controlling the speedtronic and cruise control functions, the main combination lever that operates the indicators, high beam and windscreen wipers and a stalk to adjust the steering wheel and control the optional heated steering wheel. 2016 Mercedes-Benz GLC-Class makes spectacular world premier By blogsadmin . Although we got a pretty good look. Overview; Also called: Dodge Sprinter Freightliner Sprinter Mercedes-Benz Transporter T1N Sprinter 314 (Iran) Mercedes Benz Sprinter classic (Since 2013) (Germany) Production: 1995–2006 2013-Present (As Sprinter Classic. 2016 Mercedes-Benz GLE350 SUV pricing starts at $51,100 By blogsadmin . Expected to arrive at Loeber Motors. Clearwater, FL new, Lokey Motor Company Pre-Owned Showcase sells and services Mercedes-Benz, Smart, Infiniti vehicles in the greater Clearwater area. Keys4Cars started in 2010 as a reaction to the slow and overpriced service offered at car dealerships. We provide help for individuals who are looking for faster, cheaper solutions to their numerous vehicle key problems! Controls for the interior lighting and the sun roof or panoramic sun roof are mounted on the roof, near the interior rear- view mirror. This section also includes a compartment for sun glasses. The W2. 21 is slightly larger in all dimensions than the W2. The S- Class is available in short- wheelbase form, except in the USA. If these diverge, ESP brakes single wheels selectively to eliminate oversteer (fishtailing) and understeer (plowing), and reduces engine power, if necessary. ESP includes anti- lock braking (ABS) and traction control (ASR) within its wider functions. Mercedes-Benz of El Dorado Hills Welcome to 'The Greater House' The Von Housen Family. At Mercedes-Benz of El Dorado Hills, our sales and service teams are dedicated to our customers. We strive to meet and exceed your.![]() Brake Assist and (for vehicles with the optional Distronic Plus system) Brake Assist Plus: a system that recognises emergency braking and increases the braking force (according to Mercedes- Benz 9. Brake Assist Plus uses the radar to apportion brake pressure based on sensor data and measured distance between the car and vehicles or other objects in front. Speedtronic adjustable speed limiter for not exceeding a set speed on roads with speed limits. Distronic Plus radar controlled cruise control (optional, standard cruise control on other cars), an evolution of the Distronic system introduced on the W2. Pre- Safe and Pre- Safe Plus for vehicles with Distronic Plus: a development of the previous Pre- Safe system fitted to the W2. S- Class, which uses vehicle- dynamic sensors to predict collisions and trigger precautionary measures to protect the vehicle occupants, the W2. Pre- Safe Plus system also takes into account closing speed, as measured by the vehicle's radar. If a collision appears likely, Pre- Safe closes all windows and the sunroof, moves all passenger's seats and their head restraints to a safer position, and tightens the seatbelts. ![]() It also inflates the air chambers in the side bolsters of the optional multi- contour seats and (from 2. Pre- Safe Brakes in order to reduce speed and therefore severity of impact. Bi- Xenon headlights with Active Light Function swivelling curve light. Night View Assist: optional, uses two near- infrared (NIR) illuminators mounted in the headlamp clusters and a camera in the windshield. The infrared beams are picked up by the camera and an image is displayed in the instrument cluster. ![]() ![]() Mercedes- Benz claims that this system provides the same viewable distance as high- beam headlights, without blinding oncoming motorists. Adaptive Brake Lights. Automatically dimming rear- view mirror and driver's door mirror. Seat belt pre- tensioners, belt force limiters and automatic belt height adjustment, front and rear. The W2. 21 also contains many other safety features, including front and rear crumple zones, eight dual- stage air bags, anti- lock brakes (ABS), collapsible steering column, and traction control. The Abrites diagnostics for Mercedes/Maybach/Smart is a diagnostic software application meant to be installed on a Windows based computer and used together with the Abrites Vehicle Diagnostics Interface (AVDI). Suspension and handling. Airmatic also allows the vehicle to be raised by pressing a button in order to increase ground clearance while lowering the body at higher speeds. Airmatic is the standard suspension system for all S- Class models apart from the S 6. S 6. 3, and S 6. 5 AMG which are all equipped with Active Body Control as standard. The Active Body Control (ABC) system is a more advanced suspension compared to Airmatic, based on steel springs and hydraulics, and keeps the car level even in fast corners, providing a comfort and sports setting as in the case of Airmatic. Again, the car height can be increased by using a button, increasing ground clearance for driving on difficult terrain or in snow. ![]() ABC is standard on the S 6. S 6. 3 and S 6. 5, while optional on all other models except vehicles equipped with 4. Matic all wheel drive. Tele Aid, uses GPS tracking and cell phone service to provide assistance. Can be used for information, to call for roadside assistance, or to call for help in emergencies. Automatically calls for help if an airbag or seatbelt tensioner deploys. Not available in all markets. Comfort and convenience. Seat memories are standard on some models, available as an option on others. Speed sensitive parameter steering. Electrically adjustable, folding, heated mirrors (with memory on some models). An Electric Parking Brake replaces the pedal operated system from previous generations. Optional Multi- contour seats provide additional control over lumbar, shoulder and side bolster settings in the seats, using air chambers that can be inflated or deflated to better suit the occupant and which are also used to provide a four- mode massaging function. Drive- Dynamic seats (which include the Multi- contour seat function) adds a further function to the air chamber control by inflating and deflating them dynamically to support the seat occupant during cornering. Electrically operated rear- window shade and rear side window sun shades are optionally available (standard on some models)Optional comfort head restraints are not just adjustable in height and angle, but also feature adjustable side bolsters. Self- closing doors and boot- lid are standard on some models, optionally available on others. There is also an option for a powered boot lid which closes at the touch of a button. Keyless Go, an optional smart key entry and startup system. Optional Fiber- optic Ambient Lighting package for the dashboard, doors, footwells, and other areas. A range of parking systems are available, depending on model and model year. Parktronic is an ultrasound parking aid with visual and audible signals. A rear- view camera is available as an option and models with Distronic Plus offer radar based parking assistance (Parking Assist, Advanced Parking Guidance). Bi- xenon headlamps with Headlamp Assist (automatic activation when dark) and optional Active Light System with cornering function. Electrically folding rear head restraints. Leather upholstery. Electrically adjustable steering column with easy entry function. Infrared reflecting glass, noise insulating glass. Long wheel base models have electrically adjustable rear seats (optional on other models) and the front passenger seat can be adjusted from the rear. A garage door opener integrated in the interior rear view mirror is also available. A Tyre Pressure warning system is standard, optionally a Tyre Pressure Monitoring System that displays the exact tyre pressure and warns the driver of any punctures. Multimedia. Compared to the W2. COMAND this one is even further integrated and provides access to more functions than before. The COMAND controller is now much larger, includes haptic feedback and is installed prominently on the centre console. The brightness and tilt of this screen can also be adjusted. In addition to the GPS navigation system, COMAND also offers command and control over the radio, CD/DVD, video, address book and telephone functions and can be used to control many other vehicle and equipment settings (including multi- contour seats, rear window shade and the HVAC system). 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Il loro padre, Hohenheim, ha lasciato la casa quando erano ancora piccoli, mentre alcuni anni pi. I fratelli tentano allora, tramite un'arte chiamata alchimia, di riportarla in vita, ma la trasmutazione alchemica non procede come previsto e i due devono affrontare terribili conseguenze: Edward perde una gamba mentre Alphonse l'intero corpo. Per riportare l'anima di Alphonse nel mondo umano, Edward sacrifica il suo braccio destro per legare l'anima del fratello ad un'armatura e facendosi poi rimpiazzare gli arti perduti con delle protesi meccaniche chiamate automail. Dopo la nomina di Edward ad alchimista di Stato, i due fratelli iniziano un viaggio attraverso Amestris per cercare la pietra filosofale, un oggetto alchemico capace di annullare il principio dello scambio equivalente, e riottenere cos. Durante il loro cammino, i fratelli Elric devono affrontare diversi avversari, tutti in qualche modo interessati alla pietra filosofale; tra di essi Scar, un sopravvissuto della guerra di Ishbar che trama vendetta contro gli alchimisti di Stato per aver sterminato il suo popolo, e gli homunculi, un gruppo di creature dall'aspetto umano con forti capacit. Fullmetal Alchemist Movie 2 – La Sacra. La McLaren annuncia Vandoorne-Alonso come coppia di piloti. Fullmetal Alchemist - La sacra stella di Milos, in Il mondo dei doppiatori, AntonioGenna.net.
Scoperto il piano del Padre, i fratelli Elric, insieme ad alcuni membri dell'esercito e ad altri alleati incontrati durante il cammino, decidono di contrastarlo. Durante la battaglia finale, Alphonse si sacrifica per far riottenere ad Edward il braccio mancante, grazie al quale il ragazzo distrugge la pietra filosofale del Padre. Rinunciando per sempre all'uso dell'alchimia, Edward riesce a recuperare il fratello e i due riprendono la loro vita, decidendo di viaggiare per vedere il mondo e ottenere nuove conoscenze. Le vicende presentate nella storia ruotano intorno ai due fratelli alchimisti Edward e Alphonse Elric. I due vengono spesso aiutati da Winry Rockbell, una loro amica d'infanzia e riparatrice di automail, del colonnello Roy Mustang, un alchimista di stato chiamato anche Alchimista di Fuoco, e dal maggiore Armstrong, un alchimista dotato di un fisico enorme e statuario. Durante il loro viaggio per il paese, i due fratelli incontrano diversi alleati e nemici come il criminale ishbariano Scar, i militari Maes Hughes, Riza Hawkeye, Danny Brosh e Maria Ross, altri alchimisti come Zolf J. FullMetal Alchemist Movie 2 La Sacra Stella Di Milos. FullMetal Alchemist Movie 2 La Sacra Stella Di Milos dvdrip ita, FullMetal Alchemist Movie 2 La Sacra.Kimbly e la loro maestra di alchimia Izumi Curtis, oltre ai sette homunculi, ognuno incarnante uno dei sette peccati capitali, che tentano di ricreare la pietra filosofale utilizzando il popolo di Amestris sotto ordine del Padre, il primo homunculus che caus. Nel 2. 00. 1 le venne commissionato un nuovo manga one- shot e, vedendo il buon livello qualitativo del lavoro prodotto e la relativa novit. Il 1. 2 luglio 2. ![]() Monthly Sh. L'argomento le piacque talmente tanto che cominci. Per il principio dello scambio equivalente, basato sul fatto che . Per ottenere qualcosa, . Numerosi elementi della trama, come Pinako Rockbell che accudisce i fratelli Elric dopo la morte della loro madre o Edward e Alphonse che aiutano le persone a capire il significato della famiglia sono basati su questi temi. La storia di Scar, infine, e il suo risentimento nei contronti del regime militare sono un riferimento al popolo Ainu, che si vide espropriato il suo territorio da parte di altre genti. Alcuni popoli che si insediarono nelle terre degli Ainu erano originariamente Ainu; questa ironia viene rappresentata dall'uso dell'alchimia da parte di Scar per uccidere altri alchimisti, nonostante ci. Nonostante la presenza di svariate scene dramatiche, la Arakawa cerc. I nomi di Edward ed Alphonse furono ispirati rispettivamente dal protagonista del film Edward mani di forbice e dal conte. Alphonse de Toulouse- Lautrec, mentre il cognome . Nel creare il mondo fittizio di Fullmetal Alchemist, Arakawa si . Per evitare di rendere alcuni capitoli meno divertenti di altri, rimosse da essi tutti i dettagli minori e costru. La rimozione dei dettagli superflui si rese necessaria anche perch. Inizialmente Arakawa prevedeva che la serie sarebbe durata 2. Arakawa si disse soddisfatta del suo lavoro, perch. La scrittrice infatti non voleva ripetere la stessa conclusione in entrambi i media e desiderava continuare a lavorare al manga per sviluppare ulteriormente i suoi personaggi. Vedendo il finale della serie televisiva, si sorprese nel constatare come gli homunculi fossero molto diversi dalla versione cartacea e quello che gli sviluppatori avevano immaginato per l'origine dei cattivi. Sono stati inoltre pubblicati online sul proprio sito da Square Enix gli yonkoma scritti ed illustrati dall'autrice dal 9 aprile 2. Negli Stati Uniti ed in Canada, il manga . Oltre diverse ristampe, il manga ha ottenuto anche due nuove edizioni: l'edizione Gold costituita da una dimensione maggiore dell'albo pubblicato tra il 2. Romi Park, Rie Kugimiya, Megumi Toyoguchi e T. La serie adatta solo in parte il manga, seguendo fedelmente la controparte cartacea solo per i primi volumi per poi sviluppare una storia completamente originale terminata nel film Il conquistatore di Shamballa. Gli episodi sono stati poi raccolti in 1. DVD venduti tra il 1. I costi di produzione di questa stagione per Square Enix sono stati di circa 5. Negli Stati Uniti, la serie . In seguito alla chiusura di Panini Video, la serie . I doppiatori Romi Paku e Rie Kugimiya hanno ripreso il loro ruolo di voce dei fratelli Elric mentre i nuovi doppiatori di Winry Rockbell e Roy Mustang sono Megumi Takamoto e Shinichiro Miki. Per la serie sono state composte ed interpretate 5 sigle d'apertura e 7 di chiusura. Negli Stati Uniti la serie . Per il mercato home video, Dynit ha acquistato i diritti commercializzando una edizione limitata in 4 box usciti tra il 2. La prima, Hagane no renkinjutsushi: Sareki no daichi(. La prima, pubblicata il 3. Makoto Inoue, si intitola Hagane no renkinjutsushi: Tobenai tenshi(. La quarta ed ultima light novel, scritta da S. Tre di queste, Fullmetal Alchemist Perfect Guidebook(. Un'ulteriore guida intitolata Hagane no renkinjutsushi - Hagaren kenky. Le tracce, insieme alle sigle e ad alcune reinterpretazioni effettuate da orchestre, sono state raccolte in tre CD, distribuiti da Sony, il primo contenente 3. Altri tre CD contenenti le musiche e le sigle di Fullmetal Alchemist: Brotherhood, composte da Akira Senju e nuovamente distribuite da Sony, sono stati pubblicati il 1. I cinque CD sono stati pubblicati tra il 1. Con la collaborazione del gruppo rock The Alchemists, sono stati pubblicati quattro singoli provenienti da Fullmetal Alchemist: Brotherhood reinterpretati ognuno da quattro doppiatori differenti: Romi Park, Rie Kugimiya, Mamoru Miyano e Nana Mizuki che nella serie hanno interpretato rispettivamente i ruoli di Edward Elric, Alphonse Elric, Ling Yao e Lan Fan. I primi due CD sono stati messi in vendita il 1. I tre OAV della prima serie, diretti da Seiji Mizushima e prodotti da Bones, sono stati raccolti in un DVD chiamato Fullmetal Alchemist Premium Collection uscito il 2. Il secondo, Simple na hitobito(. Il primo videogioco in assoluto, sia in Giappone sia sul mercato occidentale, ad essere pubblicato . A questi sono seguiti due giochi per PSP, Hagane no renkinjutsushi: Senaka o takuseshimono e Hagane no renkinjutsushi: Fullmetal Alchemist - Yakusoku no hi e, usciti il 1. Il primo drama- CD si intitola Hagane no renkinjutsushi vol 1: Sareki no daichi(. Sono usciti inoltre tre speciali, divisi in sei parti, commercializzati solo con la rivista Monthly Sh. La serie inoltre ha venduto oltre 1. Questi numeri sono aumentati, nel giugno 2. Giappone e 1. 3,4 milioni all'estero. Precedentemente alla trasmissione della prima serie animata, i volumi del manga si aggiravano su vendite totali di 1. Negli Stati Uniti l'opera . Anche in Italia il manga ha riscosso successo, piazzandosi sempre nella top 1. Le serie animate hanno garantito a Square Enix introiti pari a 2. Esso figura nella top 1. La prima serie animata viene annoverata tra i migliori anime del periodo in diversi sondaggi. Il personaggio di Edward Elric figura all'ottavo posto nella classifica di IGN dei migliori personaggi di anime, per via della sua multidimensionalit. Secondo l'autore Jason Thompson, nonostante parta in maniera abbastanza simile ad altri sh. Il manga riesce inoltre a narrare tematiche pi. Dello stesso avviso anche Hilary Goldstein di IGN e Jarred Pine di Mania Entertainment, i quali sottolineano la bravura di Harakawa nel bilanciare i momenti comici e quelli pi. Altri punti di forza della serie sono stati individuati nella forte personalizzazione dei personaggi, ognuno con un aspetto unico e riconoscibile nonostante molti indossino le stesse divise dell'esercito. Jeremy Crocker di Anime News Network ha dichiarato che il costante riutilizzo di personaggi e situazioni di archi narrativi precedenti contribuisce a mantenerla fresca e ad aumentare le aspettative; di diverso avviso, invece, Samuel Arbogast di T. H. E. M. Anime, il quale ha reputato i numerosi flashback noiosi. Negativo invece il giudizio di Maria Lin di Animefringe, la quale ha affermato che . |
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